CONTROLLED RELEASE ALGINATE-CHITOSAN MICROSPHERES OF TOLMETIN SODIUM PREPARED BY INTERNAL GELATION TECHNIQUE AND CHARACTERIZED BY RESPONSE SURFACE MODELING

Controlled release alginate-chitosan microspheres of tolmetin sodium prepared by internal gelation technique and characterized by response surface modeling

Tolmetin sodium (TS) is a powerful non-steroidal mitigating drug for the treatment of rheumatoid joint inflammation, osteoarthritis, and adolescent rheumatoid joint pain.In addition to its gastrointestinal (GIT) problems, TS has a short biological half-life (1 hr).In a trial to overcome these side effects cruiser-choc-chip-suede-spotted-hair and co

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Evaluation of different suspicion indices in identifying patients with Niemann-Pick disease Type C in clinical practice: a post hoc analysis of a retrospective chart review

Abstract Background Niemann-Pick disease Type C (NP-C) is a lysosomal lipid storage disorder with varying symptomatology depending on the age of onset.The diagnosis of NP-C is challenging due to heterogeneous nonspecific clinical presentation of the disease.NP-C Suspicion Index (SI) was developed to aid screening and identification of patients with

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