Controlled release alginate-chitosan microspheres of tolmetin sodium prepared by internal gelation technique and characterized by response surface modeling
Tolmetin sodium (TS) is a powerful non-steroidal mitigating drug for the treatment of rheumatoid joint inflammation, osteoarthritis, and adolescent rheumatoid joint pain.In addition to its gastrointestinal (GIT) problems, TS has a short biological half-life (1 hr).In a trial to overcome these side effects cruiser-choc-chip-suede-spotted-hair and co